Single-cell RNA sequencing characterization of Holstein cattle blood and milk immune cells during a chronic Staphylococcus aureus mastitis infection

Single-cell RNA sequencing characterization of Holstein cattle blood and milk immune cells during a chronic Staphylococcus aureus mastitis infection

Abstract Mastitis remains the most prevalent and costly disease to dairy producers. Granulocytes are the primary host innate immune cell responders during infectious mastitis. Here we examine three mid-lactation Holsteins challenged with ~ 150 CFU of Staphylococcus aureus (Newbould) that developed c...

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Bibliographic Details
Main Authors: Jayne E. Wiarda, Kaitlyn M. Sarlo Davila, Julian M. Trachsel, Crystal L. Loving, Paola Boggiatto, John D. Lippolis, Ellie J. Putz
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Single-cell
Mastitis
Staphylococcus aureus
Chronic
Neutrophil
Granulocyte
Online Access:https://doi.org/10.1038/s41598-025-96657-5
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https://doi.org/10.1038/s41598-025-96657-5

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