Design, Synthesis, and Antiproliferative Activity of Novel Indole/1,2,4-Triazole Hybrids as Tubulin Polymerization Inhibitors

Design, Synthesis, and Antiproliferative Activity of Novel Indole/1,2,4-Triazole Hybrids as Tubulin Polymerization Inhibitors

<b>Background/Objectives:</b> New indole/1,2,4-triazole hybrids were synthesized and tested for antiproliferative activity against the NCI 60 cell line as tubulin polymerization inhibitors. <b>Methods:</b> All final compounds, <b>6a</b>–<b>j</b> and &l...

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Bibliographic Details
Main Authors: Esraa Mahmoud, Dalia Abdelhamid, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif, Alaa M. Hayallah, Mohamad Abdel-Aziz
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
NCI
cancer
CA-4
tubulin
colchicine
anticancer
Online Access:https://www.mdpi.com/1424-8247/18/2/275
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