Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle

Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle

BackgroundAtherosclerosis is a leading cause of macrovascular complications in type 2 diabetes mellitus (T2DM). Lipid metabolism disorders in T2DM alter exosomal cargos, affecting vascular endothelial cells and impairing vascular endothelium-dependent relaxation.ObjectiveThis study investigates the...

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Bibliographic Details
Main Authors: Xiaojie Ruan, Wei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
type 2 diabetes mellitus
endothelial dysfunction
atherosclerosis
brown adipose tissue
exosomes
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1546325/full
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https://www.frontiersin.org/articles/10.3389/fcvm.2025.1546325/full

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