OXCT1 promotes triple negative breast cancer immune escape via modulating succinylation modification of PGK1

OXCT1 promotes triple negative breast cancer immune escape via modulating succinylation modification of PGK1

Abstract Immunotherapy has made a breakthrough in triple negative breast cancer (TNBC). The aim of this study is to investigate the specific role and regulatory mechanism of 3-oxoacid CoA-transferase 1 (OXCT1) in influencing TNBC growth and immune escape induced by aerobic glycolysis. OXCT1-induced...

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Bibliographic Details
Main Authors: Hongchen Zhang, Min Ling, Yuheng Zhang, Qing Fang, Wanlong Wo, Xiaoai Lv
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08433-w
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