OXCT1 promotes triple negative breast cancer immune escape via modulating succinylation modification of PGK1

Abstract Immunotherapy has made a breakthrough in triple negative breast cancer (TNBC). The aim of this study is to investigate the specific role and regulatory mechanism of 3-oxoacid CoA-transferase 1 (OXCT1) in influencing TNBC growth and immune escape induced by aerobic glycolysis. OXCT1-induced...

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Bibliographic Details
Main Authors: Hongchen Zhang, Min Ling, Yuheng Zhang, Qing Fang, Wanlong Wo, Xiaoai Lv
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08433-w
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