Quinoline-thiosemicarbazone-1,2,3-triazole-acetamide derivatives as new potent α-glucosidase inhibitors

Quinoline-thiosemicarbazone-1,2,3-triazole-acetamide derivatives as new potent α-glucosidase inhibitors

Abstract In this work, a novel series of quinoline-thiosemicarbazone-1,2,3-triazole-aceamide derivatives 10a-n as new potent α-glucosidase inhibitors was designed, synthesized, and evaluated. All the synthesized derivatives 10a-n were more potent than acarbose (positive control). Representatively, (...

Full description

Saved in:
Bibliographic Details
Main Authors: Aynaz Khademian, Mohammad Halimi, Reza Azarbad, Amir Hossein Alaedini, Milad Noori, Navid Dastyafteh, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Quinoline
Thiosemicarbazone
1,2,3-Triazole
α-Glucosidase inhibitors
Online Access:https://doi.org/10.1038/s41598-024-81668-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-024-81668-5

Similar Items