Anti-<i>Trypanosoma cruzi</i> Potential of New Pyrazole-Imidazoline Derivatives

Anti-<i>Trypanosoma cruzi</i> Potential of New Pyrazole-Imidazoline Derivatives

Chagas disease, caused by <i>Trypanosoma cruzi</i>, poses a significant public health challenge due to its widespread prevalence, limited therapeutic options, and adverse effects associated with available medications. In this study, we developed 13 novel pyrazole-imidazoline derivatives,...

Full description

Saved in:

Bibliographic Details
Main Authors:	Edinaldo Castro de Oliveira, Leonardo da Silva Lara, Lorraine Martins Rocha Orlando, Sarah da Costa Lanera, Thamyris Perez de Souza, Nathalia da Silva Figueiredo, Vitoria Barbosa Paes, Ana Carolina Mazzochi, Pedro Henrique Myra Fernandes, Maurício Silva dos Santos, Mirian Claudia de Souza Pereira
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Molecules
Subjects:	<i>Trypanosoma cruzi</i> pyrazole-imidazoline 3D culture model chemotherapy Chagas disease
Online Access:	https://www.mdpi.com/1420-3049/30/15/3082
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Molecular and Genetic Analysis of the Increased Number of Genes for <i>Trypanosoma cruzi</i> Microtubule Associated Proteins in the Class Kinetoplastida
by: Martin A. Winkler, et al.
Published: (2025-05-01)

Chagas, a lógica e a descoberta Chagas, the logic and the discovery
by: François Delaporte
Published: (1995-02-01)

Evaluation of a Novel Tc‐24 Recombinant Antigen ELISA for Serologic Detection of Trypanosoma cruzi Infection in Dogs: A Pilot Study
by: Rojelio Mejia, et al.
Published: (2025-09-01)

The diagnostic value of two antigenic domains derived from the Trypanosoma cruzi Tc323 protein in chronic Chagas disease: a study in Brazil
by: Micaela S. Ossowski, et al.
Published: (2025-06-01)

Identification of novel compounds against Trypanosoma cruzi using AlphaFold structures
by: Albert Ros-Lucas, et al.
Published: (2025-01-01)

Diagnóstico de tripanosomiasis americana en estudiantes de la Escuela Latinoamericana de Medicina
by: Jorge Pável Delgado La O', et al.

Prevalence of Trypanosoma Cruzi antibodies in blood donors from the Sao Paulo State, Brazil, between 2012 and 2014
by: Svetoslav Nanev Slavov, et al.
Published: (2017-03-01)

Stage-specific MCM protein expression in Trypanosoma cruzi: insights into metacyclogenesis and G1 arrested epimastigotes
by: Bruno Alves Santarossa, et al.
Published: (2025-05-01)

Different responses involving Tfh cells delay parasite-specific antibody production in Trypanosoma cruzi acute experimental models
by: Ana Carolina Leão, et al.
Published: (2025-04-01)

Molecular identification of Coranus spp. in a pregnant patient: A case of misidentified Chagas disease vector in Spain
by: Jorge Ligero-López, et al.
Published: (2025-05-01)

Characterizing the transmission dynamics of Trypanosoma cruzi in Triatoma sanguisuga collected from dog kennels in southern Texas
by: Carolina Hernandez, et al.
Published: (2025-07-01)

Imidazoline receptor agonists: more than blood pressure reduction?
by: D. V. Nebieridze, et al.
Published: (2006-04-01)

Place of imidazoline receptor agonists in the treatment of arterial hypertension
by: D. V. Nebieridze, et al.
Published: (2023-12-01)

IMIDAZOLINE RECEPTOR AGONISTS: DO WE KNOW EVERYTHING ABOUT THEIR CAPABILITIES?
by: D. V. Nebieridze, et al.
Published: (2015-12-01)

Synthesis and Characterization of Some Novel Oxazine, Thiazine and Pyrazol Derivatives
by: Baghdad Science Journal
Published: (2016-06-01)

Anti-Trypanosoma cruzi activity, cytotoxicity and, chemical characterization of extracts from seeds of Lonchocarpus cultratus
by: Aline Griebler, et al.
Published: (2021-03-01)

Synthesis and Characterization of Heterocyclic Bicyclic from the Condensation of the Pyrazole Derivatives with Aldehydes and Ketones
by: Ibtisam Taufek Ameen, et al.
Published: (2023-02-01)

Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda
by: Aziz, Katabazi, et al.
Published: (2021)

Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda
by: Aziz, Katabazi, et al.
Published: (2021)

Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections
by: Natália S. Vellozo, et al.
Published: (2025-08-01)

Rewiring the Vehicle: Trypanosoma cruzi Parasites Alter the Antennae of Their Triatomine Hosts
by: Jose D. Rivera‐Duarte, et al.
Published: (2025-03-01)

Multilocus analysis uncovers the evolution of the Rhodniini tribe, vectors of Trypanosoma cruzi
by: Carolina Hernández, et al.
Published: (2025-07-01)

Molluscicidal and Schistosomicidal Activities of 2-(1<i>H</i>-Pyrazol-1-<i>yl</i>)-1,3,4-thiadiazole Derivatives
by: Leonardo da Silva Rangel, et al.
Published: (2025-03-01)

Theory and practice of selective imidazoline receptor agonist use in Russia
by: N. I. Gaponova, et al.
Published: (2024-07-01)

Synthesis and Characterization of Some New Pyrazole, Triazole, Oxadiazole, Thiazole, Thiadiazole Derivatives Bearing p-Toluenesulfonamide
by: Maha A. Al-Hamad, et al.
Published: (2024-10-01)

Personalized approach to the treatment of patients with arterial hypertension: focus on imidazoline receptor agonists. Opinion on the problem
by: E. I. Baranova, et al.
Published: (2025-03-01)

Microwave Assisted Synthesis of Antioxidant Dihydro-Pyrazole Hybrids as Possible Lipoxygenase Inhibitors
by: Stergiani-Chrysovalanti Peitzika, et al.
Published: (2025-05-01)

Larvicidal Potential of <i>Trattinnickia Burserifolia</i> Mart. Essential Oil in Controlling the Malaria Vector in the Amazon
by: Gisele Guimarães de Oliveira, et al.
Published: (2025-04-01)

Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies
by: Bhupender Nehra, et al.
Published: (2025-06-01)

Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells
by: Felipe P. Machado, et al.
Published: (2025-07-01)

Modeling and synthesis of bifunctional dual activation thiourea organocatalysts for Michael addition of pyrazole
by: Savita Sharma, et al.
Published: (2025-12-01)

Trypanosoma dionisii in China: ecology and tentative epidemiology
by: Qin Liu, et al.
Published: (2025-07-01)

Synthesis of novel trans-2,3-dihydrofuran-pyrazole conjugates through molecular hybridization: molecular docking insights and evaluation of anti-inflammatory and anti-malarial activities
by: Ginna Kumari, et al.
Published: (2025-07-01)

Larvicidal Activity of Essential Oil, Hydrolate, and Aqueous Extract from Leaves of <i>Myrciaria floribunda</i> Against <i>Aedes Aegypti</i>
by: Eduarda Florencio Santos, et al.
Published: (2025-07-01)

Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents
by: Gadeer R.S. Ashour, et al.
Published: (2023-07-01)

TcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen Trypanosoma cruzi
by: Joshua Carlson, et al.
Published: (2025-06-01)

Fotografia e valor documentário: o arquivo de Carlos Chagas Photography and documental value: the Carlos Chagas archive
by: Aline Lopes de Lacerda
Published: (2009-07-01)

SiO2@Benzothiazole‐Cl@Fc as an Efficient Heterogeneous Catalyst for the Synthesis of 1,3,5‐Trisubstituted Pyrazoles by A3 Coupling
by: Fadhil Faez Sead, et al.
Published: (2025-08-01)

Tetrahydrodipyrazolopyridine covalently immobilized on silica-coated magnetic nanoparticles as a basic heterogeneous catalyst for multicomponent synthesis of dihydropyrano[2,3-c]pyrazole derivatives and Knoevenagel condensation
by: Ali Saffar
Published: (2025-07-01)

Efficiency of Ozone Applied in Flow and at Low Pressures in the Inactivation of <i>Salmonella</i> in Black Peppercorns (<i>Piper nigrum</i> L.) and the Effects of Ozone Treatment on Grain Quality and Essential Oil Composition
by: Handina da Graça Lurdes Langa Massango, et al.
Published: (2025-06-01)