Biomarkers of traumatic brain injury. Literature review
Traumatic brain injury (TBI) is a structural injury of brain tissue or disruption of brain function due to an external force, which causes a decreased level of consciousness, loss of memory, alterations of mental state, and neurological deficits. Head computed tomography (CT) scan is a diagnostic m...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2019-03-01
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| Series: | Neurologijos seminarai |
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| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27795 |
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| author | A. Šmigelskytė M. Remenčiūtė V. Ragaišis |
| author_facet | A. Šmigelskytė M. Remenčiūtė V. Ragaišis |
| author_sort | A. Šmigelskytė |
| collection | DOAJ |
| description |
Traumatic brain injury (TBI) is a structural injury of brain tissue or disruption of brain function due to an external force, which causes a decreased level of consciousness, loss of memory, alterations of mental state, and neurological deficits. Head computed tomography (CT) scan is a diagnostic modality of choice to evaluate patients for traumatic intracranial injuries. However, head CT scans are being overused in TBI patients. New biomarkers of TBI are being tested to avoid unnecessary head CT scans, diagnose TBI in a fast and efficient way, and determine its severity and prognosis. In the year of 2013, Scandinavian Neurotrauma Committee recommended S-100β for clinical use to predict intracranial injury on CT scans for suspected mild TBI. In the year of 2018, the US Food and Drug Administration approved a combination of GFAP and UCH-L1. Other biomarkers are also being tested for detecting TBI but they are not being used in medical practice yet.
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| format | Article |
| id | doaj-art-4b18f68d4d694360bdc4b9eeea51b3df |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-4b18f68d4d694360bdc4b9eeea51b3df2025-01-20T18:23:04ZengVilnius University PressNeurologijos seminarai1392-30642424-59172019-03-01231(79)10.29014/ns.2019.01Biomarkers of traumatic brain injury. Literature reviewA. Šmigelskytė 0M. Remenčiūtė 1V. Ragaišis 2Lithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health Sciences Traumatic brain injury (TBI) is a structural injury of brain tissue or disruption of brain function due to an external force, which causes a decreased level of consciousness, loss of memory, alterations of mental state, and neurological deficits. Head computed tomography (CT) scan is a diagnostic modality of choice to evaluate patients for traumatic intracranial injuries. However, head CT scans are being overused in TBI patients. New biomarkers of TBI are being tested to avoid unnecessary head CT scans, diagnose TBI in a fast and efficient way, and determine its severity and prognosis. In the year of 2013, Scandinavian Neurotrauma Committee recommended S-100β for clinical use to predict intracranial injury on CT scans for suspected mild TBI. In the year of 2018, the US Food and Drug Administration approved a combination of GFAP and UCH-L1. Other biomarkers are also being tested for detecting TBI but they are not being used in medical practice yet. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27795traumatic brain injurycomputed tomographybiomarkersubiquitin C-terminal hydrolase-L1glial fibrillary acidic proteinS-100 calcium-binding protein β |
| spellingShingle | A. Šmigelskytė M. Remenčiūtė V. Ragaišis Biomarkers of traumatic brain injury. Literature review Neurologijos seminarai traumatic brain injury computed tomography biomarkers ubiquitin C-terminal hydrolase-L1 glial fibrillary acidic protein S-100 calcium-binding protein β |
| title | Biomarkers of traumatic brain injury. Literature review |
| title_full | Biomarkers of traumatic brain injury. Literature review |
| title_fullStr | Biomarkers of traumatic brain injury. Literature review |
| title_full_unstemmed | Biomarkers of traumatic brain injury. Literature review |
| title_short | Biomarkers of traumatic brain injury. Literature review |
| title_sort | biomarkers of traumatic brain injury literature review |
| topic | traumatic brain injury computed tomography biomarkers ubiquitin C-terminal hydrolase-L1 glial fibrillary acidic protein S-100 calcium-binding protein β |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27795 |
| work_keys_str_mv | AT asmigelskyte biomarkersoftraumaticbraininjuryliteraturereview AT mremenciute biomarkersoftraumaticbraininjuryliteraturereview AT vragaisis biomarkersoftraumaticbraininjuryliteraturereview |