Biomarkers of traumatic brain injury. Literature review

Traumatic brain injury (TBI) is a structural injury of brain tissue or disruption of brain function due to an external force, which causes a decreased level of consciousness, loss of memory, alterations of mental state, and neurological deficits. Head computed tomography (CT) scan is a diagnostic m...

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Main Authors: A. Šmigelskytė, M. Remenčiūtė, V. Ragaišis
Format: Article
Language:English
Published: Vilnius University Press 2019-03-01
Series:Neurologijos seminarai
Subjects:
Online Access:https://www.journals.vu.lt/neurologijos_seminarai/article/view/27795
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author A. Šmigelskytė
M. Remenčiūtė
V. Ragaišis
author_facet A. Šmigelskytė
M. Remenčiūtė
V. Ragaišis
author_sort A. Šmigelskytė
collection DOAJ
description Traumatic brain injury (TBI) is a structural injury of brain tissue or disruption of brain function due to an external force, which causes a decreased level of consciousness, loss of memory, alterations of mental state, and neurological deficits. Head computed tomography (CT) scan is a diagnostic modality of choice to evaluate patients for traumatic intracranial injuries. However, head CT scans are being overused in TBI patients. New biomarkers of TBI are being tested to avoid unnecessary head CT scans, diagnose TBI in a fast and efficient way, and determine its severity and prognosis. In the year of 2013, Scandinavian Neurotrauma Committee recommended S-100β for clinical use to predict intracranial injury on CT scans for suspected mild TBI. In the year of 2018, the US Food and Drug Administration approved a combination of GFAP and UCH-L1. Other biomarkers are also being tested for detecting TBI but they are not being used in medical practice yet.
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institution Kabale University
issn 1392-3064
2424-5917
language English
publishDate 2019-03-01
publisher Vilnius University Press
record_format Article
series Neurologijos seminarai
spelling doaj-art-4b18f68d4d694360bdc4b9eeea51b3df2025-01-20T18:23:04ZengVilnius University PressNeurologijos seminarai1392-30642424-59172019-03-01231(79)10.29014/ns.2019.01Biomarkers of traumatic brain injury. Literature reviewA. Šmigelskytė 0M. Remenčiūtė 1V. Ragaišis 2Lithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health Sciences Traumatic brain injury (TBI) is a structural injury of brain tissue or disruption of brain function due to an external force, which causes a decreased level of consciousness, loss of memory, alterations of mental state, and neurological deficits. Head computed tomography (CT) scan is a diagnostic modality of choice to evaluate patients for traumatic intracranial injuries. However, head CT scans are being overused in TBI patients. New biomarkers of TBI are being tested to avoid unnecessary head CT scans, diagnose TBI in a fast and efficient way, and determine its severity and prognosis. In the year of 2013, Scandinavian Neurotrauma Committee recommended S-100β for clinical use to predict intracranial injury on CT scans for suspected mild TBI. In the year of 2018, the US Food and Drug Administration approved a combination of GFAP and UCH-L1. Other biomarkers are also being tested for detecting TBI but they are not being used in medical practice yet. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27795traumatic brain injurycomputed tomographybiomarkersubiquitin C-terminal hydrolase-L1glial fibrillary acidic proteinS-100 calcium-binding protein β
spellingShingle A. Šmigelskytė
M. Remenčiūtė
V. Ragaišis
Biomarkers of traumatic brain injury. Literature review
Neurologijos seminarai
traumatic brain injury
computed tomography
biomarkers
ubiquitin C-terminal hydrolase-L1
glial fibrillary acidic protein
S-100 calcium-binding protein β
title Biomarkers of traumatic brain injury. Literature review
title_full Biomarkers of traumatic brain injury. Literature review
title_fullStr Biomarkers of traumatic brain injury. Literature review
title_full_unstemmed Biomarkers of traumatic brain injury. Literature review
title_short Biomarkers of traumatic brain injury. Literature review
title_sort biomarkers of traumatic brain injury literature review
topic traumatic brain injury
computed tomography
biomarkers
ubiquitin C-terminal hydrolase-L1
glial fibrillary acidic protein
S-100 calcium-binding protein β
url https://www.journals.vu.lt/neurologijos_seminarai/article/view/27795
work_keys_str_mv AT asmigelskyte biomarkersoftraumaticbraininjuryliteraturereview
AT mremenciute biomarkersoftraumaticbraininjuryliteraturereview
AT vragaisis biomarkersoftraumaticbraininjuryliteraturereview