African swine fever virus infection of porcine peripheral blood monocyte-derived macrophages induces the formation of tunneling nanotube-connected large vesicle-like cell segments: a potential mechanism for intercellular ASFV trafficking

African swine fever virus infection of porcine peripheral blood monocyte-derived macrophages induces the formation of tunneling nanotube-connected large vesicle-like cell segments: a potential mechanism for intercellular ASFV trafficking

Abstract African swine fever (ASF) is a highly fatal viral disease in pigs, with mortality rates that can reach 100%. The causative agent, African swine fever virus (ASFV), primarily targets cells of the mononuclear phagocytic system (MPS), particularly monocyte-derived macrophages (MDMs). Despite t...

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Bibliographic Details
Main Authors: Brecht Droesbeke, Nadège Balmelle, Hans J. Nauwynck, Herman Favoreel, Marylène Tignon
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Veterinary Research
Subjects:
African swine fever virus
tunneling nanotubes
cytopathic effect
Online Access:https://doi.org/10.1186/s13567-025-01582-0
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https://doi.org/10.1186/s13567-025-01582-0

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