CGRP-releasing PLGA/nHA/GO composite microspheres enhance distraction osteogenesis via activation of the cAMP/PKA/CREB pathway

CGRP-releasing PLGA/nHA/GO composite microspheres enhance distraction osteogenesis via activation of the cAMP/PKA/CREB pathway

Large bone defects present significant clinical challenges, with distraction osteogenesis (DO) requiring prolonged treatment periods and yielding suboptimal outcomes. Calcitonin gene-related peptide (CGRP) demonstrates potent bone-forming activity but suffers from rapid degradation and a short half-...

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Bibliographic Details
Main Authors: Yimurang Hamiti, Kai Liu, Xin Yang, Sulong Wang, Xiriaili Kadier, Aihemaitijiang Yusufu
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
CGRP
PLGA microspheres
Distraction osteogenesis
Bone regeneration
cAMP/PKA/CREB pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007513
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