Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease

Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a highly heterogeneous disorder with distinct phenotypes that can develop well before motor symptoms appear. Recently, two main phenotypes based on the different pathological spreading patterns of PD have been proposed: “body-first”, where α-synuclein...

Full description

Saved in:
Bibliographic Details
Main Authors: Massimiliano Passaretti, Daniel Veréb, Mite Mijalkov, Yu-Wei Chang, Hang Zhao, Blanca Zufiria-Gerbolés, Jiawei Sun, Giovanni Volpe, Natalia Rivera, Matteo Bologna, Joana B. Pereira
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Body-first
Brain-first
Progression pathways
Online Access:https://doi.org/10.1186/s13024-025-00866-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13024-025-00866-5

Similar Items