A large-scale curated and filterable dataset for cryo-EM foundation model pre-training

Abstract Cryo-electron microscopy (cryo-EM) is a transformative imaging technology that enables near-atomic resolution 3D reconstruction of target biomolecule, playing a critical role in structural biology and drug discovery. Cryo-EM faces significant challenges due to its extremely low signal-to-no...

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Bibliographic Details
Main Authors: Qihe Chen, Zhenyang Xu, Haizhao Dai, Yingjun Shen, Jiakai Zhang, Zhijie Liu, Yuan Pei, Jingyi Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Data
Online Access:https://doi.org/10.1038/s41597-025-05179-2
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