ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance

ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance

Objective: Regulatory T cells (Tregs) are essential in maintaining immune tolerance and controlling inflammation. Treg stability relies on transcriptional and post-translational mechanisms, including histone acetylation at the Foxp3 locus and FoxP3 protein acetylation. Additionally, Tregs depend on...

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Main Authors: Philipp Stüve, Gloria J. Godoy, Fernando N. Ferreyra, Florencia Hellriegel, Fatima Boukhallouk, Yu-San Kao, Tushar H. More, Anne-Marie Matthies, Tatiana Akimova, Wolf-Rainer Abraham, Volkhard Kaever, Ingo Schmitz, Karsten Hiller, Matthias Lochner, Benoît L. Salomon, Ulf H. Beier, Michael Rehli, Tim Sparwasser, Luciana Berod
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Molecular Metabolism
Subjects:
ACC1
Adoptive Treg transfer
Epigenetic regulation
Fatty acid synthesis
Treg stability
Acetylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000183
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