Rational optimization of glycoprotein E (gE)-encoding mRNA for improved Varicella-zoster virus mRNA vaccine development

Rational optimization of glycoprotein E (gE)-encoding mRNA for improved Varicella-zoster virus mRNA vaccine development

mRNA platform holds promise for next-generation Varicella-zoster Virus (VZV) vaccine development due to its high potency at inducing strong T-cell response. Built upon the design of our 1st-generation VZV mRNA vaccine that encodes for full-length gE antigen, in this study we reported on a novel comb...

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Bibliographic Details
Main Authors: Lulu Huang, Shun Zhang, Tongyi Zhao, Ting Cai, Lingling Bu, Zhenhua Di, Yujie Zhang, Chen Yang, Yong Yang, Ang Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Varicella-zoster virus
mRNA vaccine
mRNA optimization
immunogenicity
T cell response
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2392661
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https://www.tandfonline.com/doi/10.1080/22221751.2024.2392661

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