Post-treatment duration of positivity for standard and ultra-sensitive Plasmodium falciparum antigen-based rapid diagnostic tests, a cohort study from a low-endemic setting in NamibiaResearch in context

Post-treatment duration of positivity for standard and ultra-sensitive Plasmodium falciparum antigen-based rapid diagnostic tests, a cohort study from a low-endemic setting in NamibiaResearch in context

Summary: Background: The standard malaria rapid diagnostic test (RDT) and newer ultra-sensitive RDT (uRDT) target Plasmodium falciparum histidine rich protein-2 (HRP2), which persists post-treatment. The duration of test positivity has not previously been studied in a low transmission setting. Meth...

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Main Authors: Henry Ntuku, Brooke Whittemore, Lucille Dausab, Ihn Kyung Jang, Allison Golden, William Sheahan, Xue Wu, Hannah Slater, Gonzalo J. Domingo, Smita Das, Elias Duarte, Lydia Eloff, Teun Bousema, Kjerstin Lanke, Cara Smith Gueye, Lisa M. Prach, Jaishree Raman, Petrina Uusiku, Stark Katokele, Roly Gosling, Bryan Greenhouse, Davis Mumbengegwi, Michelle S. Hsiang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:EBioMedicine
Subjects:
Malaria
Histidine-rich protein
Persistence
Low transmission
Low-endemic
Malaria elimination
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424005255
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http://www.sciencedirect.com/science/article/pii/S2352396424005255

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