Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury

Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury

Abstract Lipid nanoparticles (LNPs) are a promising platform for mRNA delivery. However, their use in inflammatory pulmonary diseases is limited by reactogenicity and suboptimal delivery. Here we develop a non-inflammatory LNP (NIF-LNP) by incorporating ursolic acid, identified from a natural produc...

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Main Authors: Zhiqiang Zhao, Xinzhu Shan, Jing Ding, Bin Ma, Buyao Li, Wendi Huang, Qingqing Yang, Yian Fang, Junhe Chen, Chenglin Song, Chenlong Wei, Shuai Liu, Xingdi Cheng, Shengran Zhang, Yunxuan Liu, Hongkun Wu, Cong Luo, Shaokun Shu, Xue Qiao, Zefeng Wang, Xueguang Lu, Lei Miao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61688-z
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https://doi.org/10.1038/s41467-025-61688-z

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