Independent validation and outlier analysis of EuroPOND Alzheimer’s disease staging model using ADNI and real-world clinical data

Independent validation and outlier analysis of EuroPOND Alzheimer’s disease staging model using ADNI and real-world clinical data

Abstract Background Event-based modeling (EBM) traces sequential progression of events in complex processes like neurodegenerative diseases, adept at handling uncertainties. This study validated an EBM for Alzheimer’s disease (AD) staging designed by EuroPOND, an EU-funded Horizon 2020 project, usin...

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Main Authors: Mandy M. J. Wittens, Diana M. Sima, Arne Brys, Hanne Struyfs, Ellis Niemantsverdriet, Ellen De Roeck, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul de Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaëtane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Maura Bellio, Neil P. Oxtoby, Daniel C. Alexander, Annemie Ribbens, Sebastiaan Engelborghs
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Biomarkers
Magnetic resonance imaging
Automated volumetry
Event-based modelling
Online Access:https://doi.org/10.1186/s13195-025-01788-6
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https://doi.org/10.1186/s13195-025-01788-6

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