Lyophyllum decastes-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut microbiota homeostasis

Lyophyllum decastes-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut microbiota homeostasis

IntroductionInflammatory bowel disease (IBD), including ulcerative colitis (UC), is characterized by disturbances in the intestinal barrier, immune system dysfunction, and an altered gut microbiota composition. Lyophyllum decastes, a medicinal mushroom known for its bioactive polysaccharides, has sh...

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Main Authors: Eslam Ghaleb, Yamina Alioui, Jamalat Yazeed, Natheer Wahan, Ahmed Bashah, Ali AL-waqeerah, Aamna Atta, Yuxin Sun, Yi Xin, Liang Wang, Bin Feng, Weifeng Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Lyophyllum decastes
polysaccharides
ulcerative colitis
dextran sulfate sodium (DSS)
intestinal barrier integrity
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1644325/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1644325/full

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