Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles

Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles

Abstract Background Current needle-based vaccination for respiratory viruses is ineffective at producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to the resident local pulmonary immune cells can create long-term mucosal responses. However, criteria for drug v...

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Bibliographic Details
Main Authors: Emma R. Sudduth, Aida López Ruiz, Michael Trautmann-Rodriguez, Catherine A. Fromen
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Journal of Nanobiotechnology
Subjects:
Aging
Phagocytosis
Antigen presenting cells
Pulmonary delivery
Pulmonary immunity
Nanoparticles
Online Access:https://doi.org/10.1186/s12951-024-02743-7
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https://doi.org/10.1186/s12951-024-02743-7

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