Identification of TMEM71 as a hub NLRP3-related gene suppressing malignant behavior in nasopharyngeal carcinoma via the NLRP3/Caspase-1/GSDMD signaling pathway

Identification of TMEM71 as a hub NLRP3-related gene suppressing malignant behavior in nasopharyngeal carcinoma via the NLRP3/Caspase-1/GSDMD signaling pathway

Objective: NLRP3 plays a key role in cellular pyroptosis and tumor progression. However, research on NLRP3-Related Genes (NRGs) in Nasopharyngeal Carcinoma (NPC) is limited. Methods: We analyzed the GSE53819 dataset to identify genes positively correlated with NLRP3 mRNA and downregulated in NPC tum...

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Bibliographic Details
Main Authors: Dan Liu, Yuanzhou Liu, Ruixiang Cen
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Brazilian Journal of Otorhinolaryngology
Subjects:
TMEM71
NLRP3
Caspase-1
GSDMD
Nasopharyngeal carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1808869425000096
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