Disruption of hindgut microbiome homeostasis promotes postpartum energy metabolism disorders in dairy ruminants by inhibiting acetate-mediated hepatic AMPK-PPARA axis

Disruption of hindgut microbiome homeostasis promotes postpartum energy metabolism disorders in dairy ruminants by inhibiting acetate-mediated hepatic AMPK-PPARA axis

Abstract Background Postpartum energy metabolism disorders pose a significant challenge to the health and productivity of dairy ruminants, yet their underlying pathogenesis remains poorly understood. The critical role of the gut microbiota in regulating host metabolic processes via the “gut-liver ax...

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Bibliographic Details
Main Authors: Shuo Wang, Fanlin Kong, Xinyue Zhang, Dongwen Dai, Chen Li, Zhijun Cao, Yajing Wang, Wei Wang, Shengli Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Microbiome
Subjects:
Energy metabolism disorders
Transition period
Microbiome
Cohort study
Multi-omics analysis
Microbial-host interaction
Online Access:https://doi.org/10.1186/s40168-025-02150-6
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https://doi.org/10.1186/s40168-025-02150-6

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