Chronic IL-1-Exposed LNCaP Cells Evolve High Basal p62-KEAP1 Complex Accumulation and NRF2/KEAP1-Dependent and -Independent Hypersensitive Nutrient Deprivation Response

Chronic IL-1-Exposed LNCaP Cells Evolve High Basal p62-KEAP1 Complex Accumulation and NRF2/KEAP1-Dependent and -Independent Hypersensitive Nutrient Deprivation Response

Chronic inflammation is a cancer hallmark and chronic exposure to interleukin-1 (IL-1) transforms castration-sensitive prostate cancer (PCa) cells into more fit castration-insensitive PCa cells. p62 is a scaffold protein that protects cells from nutrient deprivation via autophagy and from cytotoxic...

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Main Authors: Haley Dahl-Wilkie, Jessica Gomez, Anastasia Kelley, Kirti Manjit, Basir Mansoor, Preethi Kanumuri, Sammy Pardo, Dana Molleur, Rafah Falah, Anisha R. Konakalla, Morolake Omiyale, Susan Weintraub, Nikki A. Delk
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
chronic IL-1
HMOX1
GCLC
p62-KEAP1
NRF2
Online Access:https://www.mdpi.com/2073-4409/14/3/192
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