The causal relationship between immune cell phenotypes and esophageal cancer development: a bidirectional Mendelian randomization study

The causal relationship between immune cell phenotypes and esophageal cancer development: a bidirectional Mendelian randomization study

Abstract Background Immune cell phenotypes have been implicated in the development and progression of esophageal cancer (EC), but their causal relationships remain unclear. This study aimed to explore the potential causal associations between immune cell traits and EC risk using Mendelian randomizat...

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Main Authors: Xun Zhang, Hailang Zhou, Qianqian Meng, Weiyi Wang, Lu Zhou, Ying Xu, Haiqin Zhang, Zixu Zhang, Jinnian Cheng, Xiaopeng Zhan, Ji Li, Changping Hu, Fengli Zhou, Daming Yang, Luowei Wang, Yimin Chu, Haixia Peng
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Esophageal cancer
Immune cell phenotypes
Mendelian randomization
Genetic variants
Causal inference
Online Access:https://doi.org/10.1007/s12672-025-03175-x
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https://doi.org/10.1007/s12672-025-03175-x

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