Kujigamberol Inhibits IFN-γ and IL-2 mRNA Expression and NFATc2 Binding to Their Promoters in Response to a Phorbol Ester and Ionomycin Stimulation

Kujigamberol Inhibits IFN-γ and IL-2 mRNA Expression and NFATc2 Binding to Their Promoters in Response to a Phorbol Ester and Ionomycin Stimulation

Kujigamberol, a dinorlabdane compound isolated from Kuji amber, exerts multiple biological effects, including anti-allergic and anti-inflammatory activities. The present study demonstrated that kujigamberol inhibited cytokine production by T cells. In response to a phorbol 12-myristate 13-acetate (P...

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Bibliographic Details
Main Authors: Tanpitcha Yodweerapong, Yuto Ueno, Rikako Yamaguchi, Piimwara Yarangsee, Ken-ichi Kimura, Takao Kataoka
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
kujigamberol
NFAT
T cells
interferon γ
interleukin-2
interleukin-4
Online Access:https://www.mdpi.com/1420-3049/30/10/2214
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