Microbial bile salt hydrolase activity influences gene expression profiles and gastrointestinal maturation in infant mice

Microbial bile salt hydrolase activity influences gene expression profiles and gastrointestinal maturation in infant mice

The mechanisms by which early microbial colonizers of the neonate influence gut development are poorly understood. Bacterial bile salt hydrolase (BSH) acts as a putative colonization factor that influences bile acid signatures and microbe-host signaling pathways and we considered whether this activi...

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Main Authors: María A. Núñez-Sánchez, Florence M. Herisson, Jonathan M. Keane, Natalia García-González, Valerio Rossini, Jorge Pinhiero, Jack Daly, Milán Bustamante-Garrido, Cara M. Hueston, Shriram Patel, Nuria Canela, Pol Herrero, Marcus J. Claesson, Silvia Melgar, Ken Nally, Noel M. Caplice, Cormac G.M. Gahan
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Bile
organoid
colon
neonatal
infant
gut development
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2149023
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https://www.tandfonline.com/doi/10.1080/19490976.2022.2149023

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