Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer’s disease by repressing FoxO1 gene expression

Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer’s disease by repressing FoxO1 gene expression

Abstract Impaired brain insulin signaling is a risk factor for the pathogenesis of Alzheimer’s disease (AD). FoxO1 and HMGA1 transcription factors are involved in the pathogenesis of both type 2 diabetes (T2D) and Alzheimer’s disease (AD). This study aimed to assess the effect of vanadyl sulfate (VS...

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Bibliographic Details
Main Authors: Akram Ebrahimifar, Slahadin Ahmadi, Jalal Rostamzadeh, Kaveh Rahimi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Intracerebroventricular streptozotocin
FoxO1
HMGA1
Vanadium
Memory
Sporadic alzheimer’s disease
Online Access:https://doi.org/10.1038/s41598-025-12426-4
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https://doi.org/10.1038/s41598-025-12426-4

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