Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes

Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes

Objectives: Methylglyoxal (MG), a reactive aldehyde generated as a byproduct of glucose and lipid metabolism, is known to modify nucleic acids and proteins, altering their structure and function. While MG-induced DNA and protein adducts have been extensively studied and associated with type 2 diabet...

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Bibliographic Details
Main Authors: Edwin De Jesus Lopez Gonzalez, SWT Lai, Kelani Sun, Caree R. Carson, Carlos Hernandez-Castillo, Tala Zoukari, Kassandra Lopez, Jianying Zhang, Thomas Blevins, John Termini, Sarah C. Shuck
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
Methylglyoxal
RNA damage
Diabetes
RNA stability
RNA translation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000936
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