Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates

Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates

Liquid-liquid phase separation (LLPS) involving intrinsically disordered protein regions (IDRs) is a major physical mechanism for biological membraneless compartmentalization. The multifaceted electrostatic effects in these biomolecular condensates are exemplified here by experimental and theoretica...

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Bibliographic Details
Main Authors: Yi-Hsuan Lin, Tae Hun Kim, Suman Das, Tanmoy Pal, Jonas Wessén, Atul Kaushik Rangadurai, Lewis E Kay, Julie D Forman-Kay, Hue Sun Chan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
liquid-liquid phase separation
phosphorylation
intrinsically disordered proteins
random phase approximation
field-theoretic simulation
molecular dynamics
Online Access:https://elifesciences.org/articles/100284
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https://elifesciences.org/articles/100284

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