Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors
It has been suggested that opioid tolerance and dependence share common mechanisms with neuropathic pain. This short review deals with the role of glutamate and glutamate receptors in opioid tolerance and dependence, and neuropathic pain. Particular attention is given to the role of metabotropic glu...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2000/437256 |
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| author | Marian E Fundytus |
| author_facet | Marian E Fundytus |
| author_sort | Marian E Fundytus |
| collection | DOAJ |
| description | It has been suggested that opioid tolerance and dependence share common mechanisms with neuropathic pain. This short review deals with the role of glutamate and glutamate receptors in opioid tolerance and dependence, and neuropathic pain. Particular attention is given to the role of metabotropic glutamate receptors (mGluRs). First, the different types of glutamate receptors, which include N-methyl-D-aspartate, alpha-amino-3-hydroxyl-5-methyl- isoxazole-4-propionic acid, kainate and mGluRs, are described. Following this, evidence suggesting that these receptors are involved in opioid tolerance and dependence are summarized. At the end of this section, a model that has been previously proposed to explain mechanisms by which mGluRs may be involved in opioid tolerance and dependence are described. Next is a discussion of the evidence suggesting that glutamate receptors are similarly involved in neuropathic pain, and also in opioid sensitivity associated with neuropathic pain. Again, a hypothetical model used to explain mechanisms by which mGluRs may be involved in neuropathic pain is briefly described. The relevance of the data is discussed in terms of some of the clinical implications of the material presented in the article. |
| format | Article |
| id | doaj-art-4a4d0156f1734484b6c5fa88abdad124 |
| institution | Kabale University |
| issn | 1203-6765 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-4a4d0156f1734484b6c5fa88abdad1242025-02-03T05:46:33ZengWileyPain Research and Management1203-67652000-01-0151404810.1155/2000/437256Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate ReceptorsMarian E Fundytus0Department of Oncology, Division of Palliative Care, McGill University, Montreal, Quebec, CanadaIt has been suggested that opioid tolerance and dependence share common mechanisms with neuropathic pain. This short review deals with the role of glutamate and glutamate receptors in opioid tolerance and dependence, and neuropathic pain. Particular attention is given to the role of metabotropic glutamate receptors (mGluRs). First, the different types of glutamate receptors, which include N-methyl-D-aspartate, alpha-amino-3-hydroxyl-5-methyl- isoxazole-4-propionic acid, kainate and mGluRs, are described. Following this, evidence suggesting that these receptors are involved in opioid tolerance and dependence are summarized. At the end of this section, a model that has been previously proposed to explain mechanisms by which mGluRs may be involved in opioid tolerance and dependence are described. Next is a discussion of the evidence suggesting that glutamate receptors are similarly involved in neuropathic pain, and also in opioid sensitivity associated with neuropathic pain. Again, a hypothetical model used to explain mechanisms by which mGluRs may be involved in neuropathic pain is briefly described. The relevance of the data is discussed in terms of some of the clinical implications of the material presented in the article.http://dx.doi.org/10.1155/2000/437256 |
| spellingShingle | Marian E Fundytus Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors Pain Research and Management |
| title | Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors |
| title_full | Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors |
| title_fullStr | Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors |
| title_full_unstemmed | Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors |
| title_short | Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors |
| title_sort | common mechanisms underlying opioid tolerance and dependence and neuropathic pain role of metabotropic glutamate receptors |
| url | http://dx.doi.org/10.1155/2000/437256 |
| work_keys_str_mv | AT marianefundytus commonmechanismsunderlyingopioidtoleranceanddependenceandneuropathicpainroleofmetabotropicglutamatereceptors |