Gasdermin C promotes Stemness and Immune Evasion in Pancreatic Cancer via Pyroptosis‐Independent Mechanism

Gasdermin C promotes Stemness and Immune Evasion in Pancreatic Cancer via Pyroptosis‐Independent Mechanism

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic and lethal disease. Gasdermins are primarily associated with necrosis via membrane permeabilization and pyroptosis, a lytic pro‐inflammatory type of cell death. In this study, GSDMC upregulation during PDAC progression is report...

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Main Authors: Renfei Wu, Jingwei Li, Alexandra Aicher, Ke Jiang, Serena Tondi, Shuang Dong, Quan Zheng, Siqi Tang, Minchun Chen, Zhenyang Guo, Berina Šabanović, Preeta Ananthanarayanan, Lingxi Jiang, Anna Sapino, Chenlei Wen, Da Fu, Baiyong Shen, Christopher Heeschen
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
cancer stem cells
gasdermin C
immune evasion
invasion
immunotherapy
KRAS inhibition
Online Access:https://doi.org/10.1002/advs.202308990
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https://doi.org/10.1002/advs.202308990

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