Investigation of the cytotoxic effects and mechanisms of the SLC39A6-targeting ADC drug BRY812 in CRC

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, necessitating the development of novel therapeutic strategies. We explore the expression characteristics of SLC39A6 in CRC by combining multiple cohorts and multi-omics. The therapeutic effect and potential mecha...

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Bibliographic Details
Main Authors: Xianglin Liu, Wenqiang Liu, Yuting Wu, Yichuan Wang, Qingliang Jiang, Yangyang Li, Hengyu Li, Liqiang Hao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-03713-1
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