Endothelial HOXB9/SDC4 signaling exacerbates post-ischemic blood-brain and blood-spinal cord barrier disruption by promoting PKCα activation

Endothelial HOXB9/SDC4 signaling exacerbates post-ischemic blood-brain and blood-spinal cord barrier disruption by promoting PKCα activation

Background: Ischemic stroke is one of the most deadly chronic diseases, it damages blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB). Syndecan-4 (SDC4) affects BBB integrity and function, but the specific mechanism is unclear. Methods: The middle cerebral artery occlusion (MCAO) rat mod...

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Bibliographic Details
Main Authors: Li-Qing Wang, Xiao-Yi Wang, Zuo-Xu Fan, Jie-Sheng Zheng, Yue-Hui Ma, Heng-Jun Zhou
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Brain Research Bulletin
Subjects:
Ischemic stroke
BBB disruption
Spinal cord injury and BSCB damage
HOXB9/SDC4
PKCα activation
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025002539
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