Design and synthesis of new 1,2,3-triazole-methoxyphenyl-1,3,4-oxadiazole derivatives: selective butyrylcholinesterase inhibitors against Alzheimer’s disease

Design and synthesis of new 1,2,3-triazole-methoxyphenyl-1,3,4-oxadiazole derivatives: selective butyrylcholinesterase inhibitors against Alzheimer’s disease

Abstract Alzheimer’s disease (AD) remains a significant public health challenge due to its progressive cognitive impairment and the absence of proven treatments. In this study, several novel 1,2,3-triazole-methoxyphenyl-1,3,4-oxadiazole derivatives were synthesized and evaluated for their ability to...

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Main Authors: Aida Iraji, Roshanak Hariri, Mohammad Hashem Hashempur, Mahshad Ghasemi, Hormoz Pourtaher, Mina Saeedi, Tahmineh Akbarzadeh
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Chemistry
Subjects:
Alzheimer's disease
Butyrylcholinesterase
1,3,4-Oxadiazole
1,2,3-Triazole
Molecular dynamics
Online Access:https://doi.org/10.1186/s13065-025-01475-5
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https://doi.org/10.1186/s13065-025-01475-5

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