Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy

Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy

Hypertrophic scar is a fibrous hyperplastic disorder that arises from skin injuries. The current therapeutic modalities are constrained by the dense and rigid scar tissue which impedes effective drug delivery. Additionally, insufficient autophagic activity in fibroblasts hinders their apoptosis, lea...

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Bibliographic Details
Main Authors: Ting Wen, Yanping Fu, Xiangting Yi, Ying Sun, Wanchen Zhao, Chaonan Shi, Ziyao Chang, Beibei Yang, Shuling Li, Chao Lu, Tingting Peng, Chuanbin Wu, Xin Pan, Guilan Quan
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Hypertrophic scar
Microneedles
Autonomous drug delivery
Drug diffusion
Autophagy regulation
Fibroblast apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525003235
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