Challenges in the preclinical design and assessment of CAR-T cells

Challenges in the preclinical design and assessment of CAR-T cells

The advent of immunotherapy in the treatment of cancer has opened a new dimension in the management of this complex multifaceted disease, bringing hope to many patients whose tumors have failed to respond to conventional therapies. The adoptive T cell therapy has since been extended to the treatment...

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Main Authors: Radu Tomai, Javier De Las Rivas, Bogdan Fetica, Rui Bergantim, Brankica Filipic, Zarko Gagic, Katarina Nikolic, Diana Gulei, David Kegyes, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Richard Feder, Mariana Pavel-Tanasa, Andrei Cianga, Adrian Bogdan Tigu, Raluca Munteanu, Alina Tanase, Hermann Einsele, Ciprian Tomuleasa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
CAR-T cell tracking
tumor organoids
antigen escape
solid tumor immunotherapy
metabolic reprogramming
HDAC inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564998/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564998/full

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