Harnessing pre-trained models for accurate prediction of protein-ligand binding affinity

Abstract Background The binding between proteins and ligands plays a crucial role in the field of drug discovery. However, this area currently faces numerous challenges. On one hand, existing methods are constrained by the limited availability of labeled data, often performing inadequately when addr...

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Bibliographic Details
Main Authors: Jiashan Li, Xinqi Gong
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-025-06064-w
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