Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures

Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures

Undifferentiated pleomorphic sarcoma (UPS), an aggressive soft-tissue sarcoma of adults, has been characterized by low tumor mutational burden (TMB) and high copy number alterations. Clinical trials of programmed death-1 (PD-1) blockade in UPS have reported widely varying efficacy. We describe two p...

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Bibliographic Details
Main Authors: Drew M Pardoll, Evan Lipson, John-William Sidhom, Karim Boudadi, Robert Anders, Dung T Le, Luis A Diaz, Nicolas Llosa, Janis Taube, Lingling Chen, Teniola F Oke, Christian F Meyer, Laurene S Cheung, Thomas B Schaffer, Jillian T Ngo, John McMahon Gross, Holly Kemberling
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/6/e002345.full
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https://jitc.bmj.com/content/9/6/e002345.full

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