Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
Abstract Bacterial infections remain a major global health issue, with antimicrobial resistance (AMR) worsening the crisis. However, treatment failure can occur even when bacteria show antibiotic susceptibility in diagnostic tests. We explore factors such as phenotypic resilience, bacterial lifestyl...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-025-00113-3 |
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| _version_ | 1850124413886791680 |
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| author | Ramon Garcia-Maset Victoria Chu Nicholas Yuen Dalia Blumgart Jenny Yoon Benjamin O. Murray Amelia A. Joseph Jennifer L. Rohn |
| author_facet | Ramon Garcia-Maset Victoria Chu Nicholas Yuen Dalia Blumgart Jenny Yoon Benjamin O. Murray Amelia A. Joseph Jennifer L. Rohn |
| author_sort | Ramon Garcia-Maset |
| collection | DOAJ |
| description | Abstract Bacterial infections remain a major global health issue, with antimicrobial resistance (AMR) worsening the crisis. However, treatment failure can occur even when bacteria show antibiotic susceptibility in diagnostic tests. We explore factors such as phenotypic resilience, bacterial lifestyles such as biofilms, and differences between laboratory tests and real infection sites, highlighting the need for improved platforms to better predict treatment outcomes, and reviewing emerging technologies aimed at improving susceptibility testing. |
| format | Article |
| id | doaj-art-49d9f90c3f0b44da85fbafd0eb45759f |
| institution | OA Journals |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-49d9f90c3f0b44da85fbafd0eb45759f2025-08-20T02:34:19ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-05-013111710.1038/s44259-025-00113-3Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testingRamon Garcia-Maset0Victoria Chu1Nicholas Yuen2Dalia Blumgart3Jenny Yoon4Benjamin O. Murray5Amelia A. Joseph6Jennifer L. Rohn7Centre for Urological Biology, Department of Renal Medicine, Division of Medicine, University College LondonCentre for Urological Biology, Department of Renal Medicine, Division of Medicine, University College LondonCentre for Urological Biology, Department of Renal Medicine, Division of Medicine, University College LondonCentre for Urological Biology, Department of Renal Medicine, Division of Medicine, University College LondonCentre for Urological Biology, Department of Renal Medicine, Division of Medicine, University College LondonCentre for Urological Biology, Department of Renal Medicine, Division of Medicine, University College LondonNottingham University Hospitals NHS TrustCentre for Urological Biology, Department of Renal Medicine, Division of Medicine, University College LondonAbstract Bacterial infections remain a major global health issue, with antimicrobial resistance (AMR) worsening the crisis. However, treatment failure can occur even when bacteria show antibiotic susceptibility in diagnostic tests. We explore factors such as phenotypic resilience, bacterial lifestyles such as biofilms, and differences between laboratory tests and real infection sites, highlighting the need for improved platforms to better predict treatment outcomes, and reviewing emerging technologies aimed at improving susceptibility testing.https://doi.org/10.1038/s44259-025-00113-3 |
| spellingShingle | Ramon Garcia-Maset Victoria Chu Nicholas Yuen Dalia Blumgart Jenny Yoon Benjamin O. Murray Amelia A. Joseph Jennifer L. Rohn Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing npj Antimicrobials and Resistance |
| title | Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing |
| title_full | Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing |
| title_fullStr | Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing |
| title_full_unstemmed | Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing |
| title_short | Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing |
| title_sort | effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing |
| url | https://doi.org/10.1038/s44259-025-00113-3 |
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