Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1

Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1

Abstract Glioblastoma (GBM) is highly malignant and grows rapidly, and there is currently a lack of effective treatments. Metabolism provides the basis for the occurrence and development of GBM. Pyruvate dehydrogenase A1 (PDHA1) is a key component in both the tricarboxylic acid cycle and glycolysis,...

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Bibliographic Details
Main Authors: Yanbin Zhang, Peng Lv, Qing Zhang, Wei Xiang, Xiaobing Jiang, Zijun Guo, Tao Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Exosome
miR-21-5p
Glioma associated mesenchymal stem cells
Glioblastoma
Glycolysis
Online Access:https://doi.org/10.1038/s41598-025-86580-0
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