IL-1R2 promotes tumorigenesis and modulates the tumor immune microenvironment in colorectal cancer

IL-1R2 promotes tumorigenesis and modulates the tumor immune microenvironment in colorectal cancer

Abstract Colorectal cancer (CRC) continues to be a major global health challenge due to its high incidence and mortality rates, emphasizing the critical need for innovative therapeutic strategies. IL-1R2, a member of the IL-1 receptor family, plays a pivotal role in both tumorigenesis and antitumor...

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Bibliographic Details
Main Authors: Yanyan Lang, Hao Huang, Hongwei Jiang, Shaoxian Wu, Zhang Fang, Dachuan Zhang, Heya Qian, Yingting Liu, Maoling Yuan, Bin Xu, Lujun Chen, Xiao Zheng, Jingting Jiang
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Interleukin-1 receptor 2
Colorectal cancer
Immune checkpoint
CTLA-4
PD-1
Online Access:https://doi.org/10.1007/s00262-025-04138-5
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https://doi.org/10.1007/s00262-025-04138-5

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