Transcriptome-wide regulation of folate on neural mRNA m6A methylome via carbon metabolism in Drosophila and mammals

Abstract Increasing evidence shows that folate can regulate neural gene function through DNA modification, while regulatory roles of folate in neural RNA modification remain largely unknown. Here we show that folate treatment significantly increased Drosophila mRNA m6A levels. RNA methylation analys...

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Bibliographic Details
Main Authors: Anrui Liu, Zhengyi Huo, Zihe Xu, Sisi Liu, Yuting Jiao, Rui Li, Yi Lu, Meng Yang, Jia Huang, Chen Huang, Xiaoyun Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08623-6
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