Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice

Abstract Hepatic de novo lipogenesis (DNL) is crucial for maintaining lipid homeostasis, and its dysregulation is implicated in various metabolic diseases. While it is well established that hepatic DNL is tightly regulated by hormones such as insulin and glucagon secreted from the pancreatic islets...

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Bibliographic Details
Main Authors: Zhiyuan Li, Zheng Tian, Xiaoliu Shi, Aijun Long, Yazhuo Wang, Yan Yang, Yaqi Wang, Jingjing Zhang, Yiguo Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61963-z
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