Synergistic Neuroprotective and Immunomodulatory Effects of Cocoa Seed Husk and Guarana Extract: A Nutraceutical Approach for Parkinson’s Disease Management

Synergistic Neuroprotective and Immunomodulatory Effects of Cocoa Seed Husk and Guarana Extract: A Nutraceutical Approach for Parkinson’s Disease Management

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder linked to oxidative stress, mitochondrial dysfunction, and neuroinflammation. This study evaluates the neurofunctional and immunomodulatory effects of an aqueous extract combining cocoa seed husk and guarana powder (Gua...

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Main Authors: Vitória Farina Azzolin, Verônica Farina Azzolin, Euler Esteves Ribeiro, Juliane Santiago Sasso, Douglas Reis Siqueira, Nathalia Cardoso de Afonso Bonotto, Bárbara Osmarin Turra, Marco Aurélio Echart Montano, Ednea Aguiar Maia Ribeiro, Raquel de Souza Praia, Maria Fernanda Mânica-Cattani, Cristina Maranghello, Railla da Silva Maia, Erickson Oliveira dos Santos, Pedro Luis Sosa Gonzalez, Cleideane Cunha Costa, Vanusa Nascimento, Fernanda Barbisan, Ivana Beatrice Mânica da Cruz
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antioxidants
Subjects:
functional foods
<i>Theobroma cacao</i>
<i>Paullinia cupana</i>
flavonoids
Online Access:https://www.mdpi.com/2076-3921/14/3/348
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