Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway

Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway

Abstract Hepatic ischemia-reperfusion injury (IRI) is a common complication of hepatectomy and liver transplantation. As far as we know, mild hypothermia (MH) is an effective measure to alleviate liver IRI. However, the precise mechanisms have not been fully elucidated. This study investigated the r...

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Bibliographic Details
Main Authors: Zhongshan Lu, Hao Chen, Anxiong Liu, Shufang Na, Wei Wang, Zibiao Zhong, Qifa Ye
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Mild hypothermia
Ischemia-reperfusion injury
FoxO1
PPARα
Fatty acid oxidation
Gluconeogenesis
Online Access:https://doi.org/10.1038/s41598-025-09725-1
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https://doi.org/10.1038/s41598-025-09725-1

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