Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity

Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity

Abstract B7H3, an immune checkpoint molecule, is a highly N-glycosylated membrane protein. However, the key glycosylated asparagine residues that mediate the function of the B7H3 protein are still unclear. Here we identify that N-glycans attached to asparagine residues N91/309 and N104/322 are requi...

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Main Authors: Yun Huang, Wen-Qing Zhong, Xiao-Yu Yang, Jia-Lu Shan, Ling Zhou, Zhi-Ling Li, Yi-Qing Guo, Kai-Ming Zhang, Tian Du, Hai-Liang Zhang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Gong-Kan Feng, Jun Tang, Xiao-Feng Zhu, Rong Deng
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58740-3
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https://doi.org/10.1038/s41467-025-58740-3

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