MKRN1 degrades AGC1 to trigger chemotherapy resistance of colorectal Cancer

MKRN1 degrades AGC1 to trigger chemotherapy resistance of colorectal Cancer

Abstract Oxaliplatin (Oxa) has been extensively employed in treatment of colorectal cancer (CRC), yet frequent occurrence of chemoresistance poses a significant obstacle to achieving long-term disease-free survival for CRC patients. In this study, we employed a CRISPR/Cas9 sgRNA library targeting 1,...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yixuan Wang, Mu Qiao, Jing Guo, Ying Xie, Meilin Hu, Xin Li, Sheng Wang, Jingjing Wang, Jingya Wang, Ziyi Peng, Mengqi Wang, Hao Cheng, Tiantian Li, Linchuang Jia, Danchen Su, Huanhuan Liu, Kexin Hu, Xinyang Li, Wenjing Li, Di Wu, Zhe Zhang, Jianing Han, Ruiyang Bai, Funan Zhou, Zhiqiang Liu
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Molecular Medicine
Subjects:	Colorectal cancer Ubiquitination MKRN1 AGC1 Heat shock proteins Mitochondrial energy metabolism
Online Access:	https://doi.org/10.1186/s10020-025-01287-2
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Genetic variants of the DLK1, KISS1R, MKRN3 genes in girls with precocious puberty
by: E. A. Sazhenova, et al.
Published: (2025-04-01)

AGC Including ELD and Emission Coordination Using Sine Cosine Algorithm
by: Ahmed Oday Oleiwi, et al.
Published: (2021-09-01)

A novel model of central precocious puberty disease: Paternal MKRN3 gene–modified rabbit
by: Bangzhu Chen, et al.
Published: (2025-03-01)

Scalable Δ -AGC Logic for Enhanced Electromechanical Oscillation Damping in Modern Power Systems With Utility-Scale Photovoltaic Generators
by: Rajan Ratnakumar, et al.
Published: (2025-01-01)

CHARACTERISTICS OF DIGITAL AGC IN FIXED-POINT OPERATIONS
by: A. A. Prasolov
Published: (2019-04-01)

Genome wide identification of AGC kinase genes and their expression in response to heat and cold stresses in barley
by: Zohreh HAJIBARAT, et al.
Published: (2022-10-01)

Centennial spatiotemporal evolution of AGC in subtropical forests and key driving factors − based on process modeling and geography detector
by: Lei Huang, et al.
Published: (2025-09-01)

A Novel Hierarchical/Decentralized AGC Scheme for Power Systems Integrated With Large-Scale Solar Power Plants
by: Siavash Yari, et al.
Published: (2025-01-01)

tRFAla-AGC-3-M8 attenuates neuroinflammation and neuronal damage in Alzheimer’s disease via the EphA7-ERK1/2-p70S6K signaling pathway
by: Zihao Deng, et al.
Published: (2025-05-01)

Performance Indices of Electrochemical Energy Storage for AGC Control Based on the Discrete Fréchet Algorithm
by: Hao HUANG, et al.
Published: (2020-01-01)

HUWE1 is involved in Sertoli cell polarity establishment by ubiquitination mediated degradation of WT1
by: Bowen Liu, et al.
Published: (2025-07-01)

Bi-Objective Optimization of Real-Time AGC Dispatch in Performance-Based Frequency Regulation Market
by: Xiaoshun Zhang, et al.
Published: (2024-01-01)

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression
by: Dan Jian, et al.
Published: (2025-07-01)

Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration
by: Cong Chen, et al.
Published: (2025-07-01)

TRIM3 suppressed the tumorigenicity of melanoma cells by ubiquitinating YAP1
by: Yi-tong Wang, et al.
Published: (2025-07-01)

NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer
by: Guang Yang, et al.
Published: (2025-06-01)

E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases
by: Li Zhu, et al.
Published: (2025-02-01)

ZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis
by: Xinjun Li, et al.
Published: (2025-06-01)

Clinical Significance of the Serum 3&prime;tRF-AlaAGC, Neutrophil to High-Density Lipoprotein Ratio, and Lymphocyte-to-Monocyte Ratio in Breast Cancer with Lymph Node Metastasis
by: Mo D, et al.
Published: (2025-05-01)

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions
by: Qiwei Jiang, et al.
Published: (2021-08-01)

Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer
by: Li Cheng, et al.
Published: (2025-06-01)

Identification of potential substrates of LNX1 in chicken cells
by: Yuhong Liu, et al.
Published: (2025-01-01)

DYNLL1 ubiquitinated and degraded by E3 ligase PRKN regulates cell cycle arrest and apoptosis in lung adenocarcinoma cells
by: Hongjie Tang, et al.
Published: (2024-12-01)

TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27
by: Vanajothi Ramar, et al.
Published: (2025-07-01)

Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
by: Stefanie Peter, et al.
Published: (2014-09-01)

Hypoxia promotes pancreatic adenocarcinoma progression by stabilizing ID1 via TRIM21 suppression
by: Rui Cheng, et al.
Published: (2025-08-01)

The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1
by: Ying Tong, et al.
Published: (2025-07-01)

AGC of a Multi‐Area Hydrothermal Interconnected Diverse Deregulated Power System Using a Proposed Novel SBOA‐Multi‐Level Fuzzy Logic‐Tilt Controller Incorporated With IPFC
by: Getaneh Mesfin Meseret, et al.
Published: (2025-06-01)

The Arabidopsis E3 ubiquitin ligase PUB13 synergistically interacts with BON1 to regulate plant flowering and immunity
by: Jiani Yue, et al.
Published: (2025-06-01)

Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition
by: Chengyu Li, et al.
Published: (2025-08-01)

Targeting PD-1 post-translational modifications for improving cancer immunotherapy
by: Jie Shi, et al.
Published: (2025-06-01)

Variant pubertal development in Prader-Willi syndrome: early and slow progression of pubarche with normal age at gonadarche
by: Aneta Kodytková, et al.
Published: (2025-04-01)

FBXO10 Drives Hepatocellular Carcinoma Proliferation via K63-Linked Ubiquitination and Stabilization of FRMPD1
by: Wuguang Liu, et al.
Published: (2025-05-01)

Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis
by: Yidi Jia, et al.
Published: (2025-02-01)

WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer
by: Hao Jiang, et al.
Published: (2024-12-01)

SPC25 upregulates CCND1 to promote the progression of esophageal squamous cell carcinoma by inhibiting MDM2-mediated E2F1 ubiquitination
by: Haoyao Jiang, et al.
Published: (2025-03-01)

Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress
by: Jing Chen, et al.
Published: (2025-09-01)

GADD45GIP1 promotes osteosarcoma progression by modulating RPL35 ubiquitination and alleviating endoplasmic reticulum stress via the PERK/eIF2α pathway
by: Zhiqiang Li, et al.
Published: (2025-07-01)

Clinical and functional characterization of a novel STUB1 mutation in a Chinese spinocerebellar ataxia 48 pedigree
by: Jiaqi Li, et al.
Published: (2024-12-01)

COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis
by: Yuxiao Zheng, et al.
Published: (2025-05-01)