MKRN1 degrades AGC1 to trigger chemotherapy resistance of colorectal Cancer

MKRN1 degrades AGC1 to trigger chemotherapy resistance of colorectal Cancer

Abstract Oxaliplatin (Oxa) has been extensively employed in treatment of colorectal cancer (CRC), yet frequent occurrence of chemoresistance poses a significant obstacle to achieving long-term disease-free survival for CRC patients. In this study, we employed a CRISPR/Cas9 sgRNA library targeting 1,...

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Main Authors: Yixuan Wang, Mu Qiao, Jing Guo, Ying Xie, Meilin Hu, Xin Li, Sheng Wang, Jingjing Wang, Jingya Wang, Ziyi Peng, Mengqi Wang, Hao Cheng, Tiantian Li, Linchuang Jia, Danchen Su, Huanhuan Liu, Kexin Hu, Xinyang Li, Wenjing Li, Di Wu, Zhe Zhang, Jianing Han, Ruiyang Bai, Funan Zhou, Zhiqiang Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Medicine
Subjects:
Colorectal cancer
Ubiquitination
MKRN1
AGC1
Heat shock proteins
Mitochondrial energy metabolism
Online Access:https://doi.org/10.1186/s10020-025-01287-2
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https://doi.org/10.1186/s10020-025-01287-2

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