Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart

Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart

Abstract Background Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberrant activation of signaling pathways in a diabetic heart. Epigenetic mark...

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Main Authors: Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Epigenetics & Chromatin
Subjects:
Diabetic cardiomyopathy
Epigenetics
DNA methylation
DNA hydroxymethylation
5mC
5hmC
Online Access:https://doi.org/10.1186/s13072-023-00489-4
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https://doi.org/10.1186/s13072-023-00489-4

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