Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer

Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer

Abstract The ATP-hydrolytic ectoenzyme ENPP1 has been implicated in the metastasis and recurrence in triple-negative breast cancer (TNBC), primarily by contributing to tumor cell survival and treatment resistance. However, the precise mechanisms remain unclear. In a model of local recurrence (LR), c...

Full description

Saved in:
Bibliographic Details
Main Authors: Borja Ruiz-Fernández de Córdoba, Karmele Valencia, Connor Welch, Haritz Moreno, Susana Martínez-Canarias, Carolina Zandueta, Eduardo Gómez, Alfonso Calvo, Nerea Otegui, Mirari Echepare, Ignacio Garzón, Daniel Ajona, David Lara-Astiaso, Elisabeth Guruceaga, Laura Guembe, Rubén Pío, Ignacio Melero, Silve Vicent, Fernando Pastor, Rafael Martínez-Monge, Fernando Lecanda
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02271-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41392-025-02271-2

Similar Items